Peptide Chemicals


Amino Acid Derivatives

Proprietary know-how in single step tert. Butylation technology at ORPEGEN Pharma provides large scale production of all N-protected amino acid tert. Butylation derivates at competitive prices. The flexibility in reactor capacity ensures bulk production of important protected amino acids.

  • Fmoc, Boc, Ddz and Z Amino Acids
  • Pre-loaded Wang resins and otherwise linked amino acids on polymer support, e.g. HYCRAM

The manufacturing of the amino acid derivates is performed in glass or stainless steel reactors for production runs up to 200 kg per batch. ORPEGEN Pharma uses only raw materials and solvents of highest quality after passing rigorous quality control procedures. Each lot of amino acid derivatives manufactured is checked for enantiomeric purity, acetate and ß-alanine content if any, and is accompanied by a BSE/TSE-risk free certificate.

Pharmaceutical Peptides

ORPEGEN Pharma has in house pharmaceutical GMP production capacity and know how for generic synthetic peptide hormones (Oxytocin, LHRH, Somatostatin, Eledoisin, MCD-Peptide, Insulin, Calcitonin, Bradykinin, Nociceptin) and thymic peptides, e.g. Thymosin-a1, Twin- a1 and Thymosin-a1 related shorter peptides, antigenic determinants. Pre-loaded Wang resins and otherwise linked amino acids on solid supports are applied in SPPS on large scale for non-destructive peptide detachment, including the noble metal-catalysed HYCRAM® release technology of OPRPEGEN.

All this capacity is based on in-house manufacture of more than 350 amino acid derivates at industrial scale.

Solid and Solution Phase Peptide Synthesis

  • Large Scale Solid Phase Peptide Synthesis (kg to mg) on all common polymer supports
  • Multiple kg-synthesis of Peptides in solution
  • Optimized chemical strategies Fmoc-/ tert.Butyl, Boc-/Benzyl, Z-/ tert.Butyl, Ddz-/ tert.Butyl, based on ORPEGEN Pharma pharmaceutical grade amino acid derivatives.

Chemically Modified Peptides
  • Glycosylation
  • Biotinylation
  • Palmitinoylation, Pegylation and others

Quality Control and Quality Assurance

  • Analytical know-how approved by FDA and international pharmaceutical industry contractors
  • Quality control according to Good Manufactoring & Laboratory Practice (GMP/GLP)
  • Confirmed certificate of the final pharmaceutical product